Anti-IL33, clone CL13438

Interleukin-33 - Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). [The UniProt Consortium] Enhanced validation: Yes. Concentration: 1 mg/ml. Immunogen homology (mouse/rat): ENSMUSG00000024810: 48%, ENSRNOG00000016456: 50%. Buffer formulation: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.