Anti-IL-1B, clone B-B53 (azide free)

Specificity: Recognizes natural and recombinant human IL-1beta. Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free.Storage: Stable at +2-8°C for 12 months. For longer storage freeze aliquots. Protein function: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). [The UniProt Consortium]