Anti-ICOS / Inducible T-cell costimulator / CD278, clone RM417

Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This antibody reacts to human ICOS/CD278. Protein function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching of immunoglobin isotypes. [The UniProt Consortium]