Anti-ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody (RM417)

Inducible T cell co-stimulator (ICOS), also known as CD278, is a glycoprotein and member of the CD28/B7 family of co-stimulatory receptors that promotes T cell activation. It exists as a membrane-bound disulfide-linked homodimer and contains a leader peptide, an extracellular domain that interacts with ICOS ligand (ICOSL), and a cytoplasmic tail that mediates association with PI3K and is critical for T cell activation. ICOS is expressed on activated CD4+ and CD8+ T cells following T cell receptor crosslinking and/or co-stimulation by CD28. ICOS co-stimulation of T cells induces production of IL-4, IL-5, IL-6, IFN-gamma (Cay-32008, Cay-32078), TNF-alpha (Cay-32020, Cay-32069), and GM-CSF (Cay-32044, Cay-32079), but not IL-2, and superinduces production of IL-10, as well as prevents T cell apoptosis. Human melanoma cells express ICOSL and promote the expansion of ICOS+ IL-10-secreting regulatory T cells, which is positively correlated with unfavorable clinical outcomes. Administration of an anti-ICOS monoclonal antibody ameliorates mucosal inflammation and damage in a mouse model of T helper cell-induced chronic colitis. Cayman's ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody (RM417) can be used for immunohistochemistry (IHC) applications.Synonyms: Activation-inducible Lymphocyte Immunomediatory Molecule, Inducible T cell Co-Stimulator. Immunogen: Peptide from the C-terminal region of human ICOS. Clone Designation: RM417. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC. Cross Reactivity: (+) ICOS.