Anti-human CD45, clone HI100, iFluor(R) 633

Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. [The UniProt Consortium] This antibody was purified through affinity chromatography and conjugated to iFluor(TM) 633 (ex/em = 640/654 nm). It is compatible with the 633 nm laser and 670/30 nm bandpass filter (for example, as in the BD FACSCelesta(TM)).