Anti-HSD17B2

17beta-HSD2 (17beta hydroxysteroid dehydrogenase type 2) belongs to the 17beta-HSD family of proteins that regulate the availability of steroids within a tissue. 17beta-HSD2 converts active steroids to their inactive form through its oxidative activity. It is a key player in the inactivation of Estradiol and testosterone. Due to the affects that 17beta-HSD2 has on the availability of estrogen, it has been extensively investigated for playing a possible role in breast tumor development, colon cancer development and the pathophysiology of endometriosis. Protein function: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. [The UniProt Consortium]