Anti-Hsc70 (Hsp73)

Anti-Hsc70 (Hsp73) Antibody was prepared from monospecific antiserum by delipidation and defibrination. A BLAST analysis was used to suggest cross-reactivity with Hsc70 (Hsp73) from Human and Hamster based on 100% homology with the immunizing sequence. Does not cross-react with hsp70. Cross-reactivity with Hsc70 (Hsp73) from other sources has not been determined. Heat Shock research. Protein function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. [The UniProt Consortium]