Anti-HOXB4

HoxB4 is a member of the highly conserved homeodomain TF (Transcription Factor) family. It was the first transcription factor shown to lead to profound HSC (hematopoietic stem cells) expansion in vitro and in vivo when expressed ectopically in adult BM cells and ESCs (Embryonic Stem Cells). HoxB4 is used to promote hematopoietic differentiation from human embryonic stem cells or from human induced pluripotent stem cells. Protein function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. [The UniProt Consortium]