Anti-HMGB1 (Clone IMG19N15F4)

High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.Synonyms: High Mobility Group Protein B1, HMG1. Immunogen: full length recombinant human HMGB1. Clone Designation: IMG19N15F4. Formulation: (Request formulation change), 100 µg of Protein G purified IgG1kappa in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Host: Mouse. Isotype: IgG1?. Applications: FC, IHC (paraffin-embedded tissue), and WB.