Anti-Hepsin

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Hepsin, also known as TMPRSS1, is an enzyme that in humans is encoded by the HPN gene. Tsuji et al.(1991) mapped the gene to 19q11-q13.2. Using cDNA microarrays, Dhanasekaran et al.(2001) examined gene expression profiles of more than 50 normal and neoplastic prostate specimens and 3 common prostate cancer cell lines. Signature expression profiles of normal adjacent prostate, benign prostatic hypertrophy, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. In 3 different human cell lines, Guipponi et al.(2008) found that Hepsin was stably anchored in the endoplasmic reticulum. Protein function: Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2. [The UniProt Consortium]