Anti-HBEGF

Anti-HBEGF
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ELK-ES11256.50 50 µl - -

Fragen Sie uns nach der Lieferzeit

169,00 €
ELK-ES11256.100 100 µl - -

Fragen Sie uns nach der Lieferzeit

283,00 €
 
function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for... mehr
Produktinformationen "Anti-HBEGF"
function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,similarity:Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor., Protein function: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor., [Proheparin-binding EGF-like growth factor]: Cell membrane, Single-pass type I membrane protein.
Schlagworte: Anti-DTR, Anti-HBEGF, HBEGF rabbit pAb
Hersteller: ELK Biotechnology
Hersteller-Nr: ES11256

Eigenschaften

Anwendung: WB, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, rat, mouse
Immunogen: Synthesized peptide derived from human protein . at AA range: 130-210
MW: 22 kD
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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