Anti-GRB2

In 1X PBS, pH 7.4, with 0.09% sodium azide. GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Protein function: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. [The UniProt Consortium]