Anti-GPVI

Anti-GPVI Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with GPVI from other sources has not been determined. Protein function: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. [The UniProt Consortium]