Anti-GPNMB

glycoprotein nmb(GPNMB) Homo sapiens The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], Protein function: Could be a melanogenic enzyme. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cell membrane, Single-pass type I membrane protein . Melanosome membrane , Single-pass type I membrane protein . Early endosome membrane , Single-pass type I membrane protein . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .