Anti-FLIP

Anti-FLIP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Antibody recognizes human and murine FLIPgamma and FLIPdelta but not FLIPalpha and FLIPbeta. Protein function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. [The UniProt Consortium]