Anti-Filamin A / FLNA

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F54947-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F54947-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Actin-binding protein 280, or filamin, is a 280-kD... mehr
Produktinformationen "Anti-Filamin A / FLNA"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Actin-binding protein 280, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers. Protein function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). [The UniProt Consortium]
Schlagworte: Anti-FLN, Anti-FLNA, Anti-FLN-A, Anti-ABP-280, Anti-Filamin-1, Anti-Filamin-A, Anti-Alpha-filamin, Anti-Non-muscle filamin, Anti-Actin-binding protein 280, Anti-Endothelial actin-binding protein, Filamin A Antibody / FLNA
Hersteller: NSJ Bioreagents
Hersteller-Nr: F54947

Eigenschaften

Anwendung: FC, IF, IHC (paraffin), WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 1025-1054 from the human protein
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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