Anti-EPRS / Proline--tRNA ligase

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-RQ6380 100 µg - -

3 - 10 Werktage*

755,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Bifunctional aminoacyl-tRNA synthetase is... mehr
Produktinformationen "Anti-EPRS / Proline--tRNA ligase"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Bifunctional aminoacyl-tRNA synthetase is an enzyme that in humans is encoded by the EPRS1 gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. Protein function: Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS1 function from protein synthesis to translation inhibition (PubMed:15479637, PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). [The UniProt Consortium]
Schlagworte: Anti-EPRS, Anti-GluRS, Anti-PIG32, EC=6.1.1.17, Anti-Proline--tRNA ligase, Anti-Prolyl-tRNA synthetase, Anti-Glutamate--tRNA ligase, Anti-Glutamyl-tRNA synthetase, Anti-Glutamatyl-prolyl-tRNA synthetase, Anti-Bifunctional aminoacyl-tRNA synthetase, EPRS A
Hersteller: NSJ Bioreagents
Hersteller-Nr: RQ6380

Eigenschaften

Anwendung: WB, IHC (paraffin), IF, FC, Direct ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant human protein (amino acids R1298-Y1512)
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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