Anti-Epigen

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012], Protein function: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.. Cellular localization: [Isoform 1]: Membrane , Single-pass type I membrane protein ., [Isoform 2]: Membrane , Single-pass type I membrane protein ., [Isoform 3]: Secreted ., [Isoform 4]: Secreted ., [Isoform 5]: Secreted ., [Isoform 6]: Secreted .