Anti-Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351)

Cytokeratin 17 (CK-17) is an intermediate filament protein and a member of the cytokeratin protein family encoded by KRT17 in humans. It is a type I acidic cytokeratin expressed in the basal cells of epithelial appendages, such as hair follicles and sebaceous glands, and is localized to the cytoplasm. CK-17 expression can be induced in the epidermis under conditions of cellular stress, such as viral infection, injury, or psoriasis. CK-17 is also expressed in squamous, basal, and urothelial carcinomas, as well as adenocarcinomas, and is associated with poor prognosis in breast, cervical, oral squamous, and gastric carcinomas. Heterozygous dominant mutations in KRT17 are associated with early onset alopecia. Missense mutations in KRT17 are associated with ectodermal dysplasias, including pachyonychia congenita and steatocystoma multiplex. Cayman's Cytokeratin 17 (C-Term) Rabbit Monoclonal Antibody (Clone RM351) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: CK-17, Keratin-17, Keratin, Type II Cytoskeletal 17, KRT17. Immunogen: Peptide from the C-terminal region of human cytokeratin 17. Clone Designation: RM351. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Cytokeratin 17.