Anti-CNOT4 (CCR4-NOT Transcription Complex Subunit 4, CCR4-associated Factor 4, E3 Ubiquitin-protein

Anti-CNOT4 (CCR4-NOT Transcription Complex Subunit 4, CCR4-associated Factor 4, E3 Ubiquitin-protein
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
C2099-68W1.100 100 µg - -

3 - 19 Werktage*

629,00 €
 
CNOT4 is a 575aa protein with E3 ubiquitin ligase activity, mainly involved in protein... mehr
Produktinformationen "Anti-CNOT4 (CCR4-NOT Transcription Complex Subunit 4, CCR4-associated Factor 4, E3 Ubiquitin-protein"
CNOT4 is a 575aa protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal. Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.05-0.1ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human skeletal muscle lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: EC=6.3.2.-, Anti-CCR4-associated factor 4, Anti-E3 ubiquitin-protein ligase CNOT4, Anti-CCR4-NOT transcription complex subunit 4, Anti-Potential transcriptional repressor NOT4Hp
Hersteller: United States Biological
Hersteller-Nr: C2099-68W1

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: bovine, chicken, human, mouse, rat, xenopus
Immunogen: Synthetic peptide corresponding to aa50-100 of human CNOT4.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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