Anti-CD54 (ICAM-1, Intercellular Adhesion Molecule1, Human Rhinovirus Receptor, BB2, Major group rhi

The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset, it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43. ICAM-1 is an essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically , with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leukocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments. ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes. , , Applications:, Suitable for use in staining of in vitro cultured cells, Immunohistochemistry (frozen and paraffin), Immunoassays, and Immunoprecipitation. Recommended Dilution: Immunohistochemistry: 1:50, Immunoprecipitation: 1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.