Anti-CD46, clone AEI-3

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-RQ5487 100 µl - -

3 - 10 Werktage*

755,00 €
 
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The protein encoded... mehr
Produktinformationen "Anti-CD46, clone AEI-3"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The protein encoded by the CD46 gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. [RefSeq] Protein function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. [The UniProt Consortium]
Schlagworte: Anti-MCP, Anti-TLX, Anti-CD46, Anti-Membrane cofactor protein, Anti-Trophoblast leukocyte common antigen, CD46 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: RQ5487

Eigenschaften

Anwendung: IHC (paraffin), WB
Antikörper-Typ: Monoclonal
Klon: AEI-3
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A synthetic peptide specific to human CD46
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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