Anti-CD24 (Clone: ML1)

The antigen is CD24 with a molecular weight of 35 - 45kD. The epitope has not been further characterized. Antigen distribution: Isolated cells: granulocytes. Tissue sections: B-cells (germinal centers weak), follicular dendritic cells, variety of epithelial cell types. Protein function: May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. [The UniProt Consortium]