Anti-Caspase-7

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Caspase-7 is a human protein encoded by the CASP7 gene. Orthologs have been identified in nearly all mammals for which complete genome data are available. CASP7 is a member of the cysteine aspartate protease family of proteins, and has been shown to be an executioner protein of apoptosis. Using radiation hybrid mapping, the CASP7 gene was localized to human chromosome 10q25.1-q25.2. The orderly activation of the protein regulates microglia activation through a protein kinase C-delta (PRKCD)-dependent pathway. Protein function: Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:8521391, PubMed:8576161, PubMed:8567622, PubMed:9070923, PubMed:11701129). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8521391, PubMed:8576161, PubMed:8567622, PubMed:9070923). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-, -Gly-217' bond. Overexpression promotes programmed cell death (PubMed:8521391, PubMed:8576161, PubMed:8567622, PubMed:9070923). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9. [The UniProt Consortium]