Anti-Carboxypeptidase B2

CPB2 (Carboxypeptidase B2, also CPU and TAFI) is a secreted,50-60 kDa glycoprotein member of the peptidase M14 family of enzymes. It is expressed by hepatocytes (60 kDa) and platelets (50 kDa),with MW differences attributable to glycosylation. CPB2 is cleaved by thrombin and plasmin,generating a 36 kDa,relatively insoluble nonglycosylated enzymatically active fragment (TAFIa). Protein function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. [The UniProt Consortium]