Anti-Calretinin (N-Term) Rabbit Monoclonal Antibody (Clone RM324)

Calretinin is a calcium-binding protein and member of the large EF-hand protein family that is encoded by CALB2 in humans. It is composed of six EF-hand domains, each of which contains two alpha-helices oriented perpendicular to each other around a calcium-binding domain. Calretinin is expressed in specific neuronal populations, including granule cells of the cerebellum, auditory neurons, and retinal neurons, and is localized to the cytosol where it has a role in the modulation of neuronal excitability. It is also expressed under pathological conditions, particularly in epithelial mesothelioma cells and colon adenocarcinomas. Calb2-/- mice exhibit impaired induction of long-term potentiation following tetanic hippocampal stimulation. Levels of calretinin are increased in the dorsomedial and ventromedial hypothalamic nuclei in aged rats. Cayman's Calretinin (N-Term) Rabbit Monoclonal Antibody (Clone RM324) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: 29 kDa Calbindin, CAB29, CAL2, Calbindin 2. Immunogen: Peptide from the N-terminal region of human calretinin. Clone Designation: RM324. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC and WB. Cross Reactivity: (+) Calretinin.