Anti-CACYBP (S100A6-binding protein, Siah-interacting protein)

CACYBP(Calcyclin-binding protein), also called SIP, is a protein that in humans is encoded by , the CACYBP gene. The full-length SIP cDNA encodes a predicted 228-amino acid protein. Sequence , analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the , deduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, , SIP-short (SIPS). The CACYBP gene is mapped on 1q25.1. It may be involved in calcium-dependent , ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a , molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of , beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found , for this gene. The C-terminal region of SIP that is homologous to SGT1 was able to complement , defects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP , protein function. UniProt Number: Q9HB71, Gene ID: CACYBP, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.