Anti-B7-H4, clone ABM53A6

B7-H4, a member of B7 family, is a transmembrane protein that has been shown to inhibit T cell responses and neutrophil expansion during bacterial infections. B7-H4 mRNA is widely distributed in mouse and human peripheral tissues and can be induced in monocytes, macrophages, and dendritic cells upon IL-6 and IL-10 stimulation. However, in a variety of tumor cells, B7-H4 is predominantly present in intracellular compartments with unknown mechanism and functions. Cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. The overexpression of B7-H4 has been found in various types of human tumors, such as breast cancer, renal cell carcinoma (RCC), ovarian cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer and melanoma etc, where its expression level is positively correlated with disease progression. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Protein function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. [The UniProt Consortium]