Anti-ATRIP

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. [The UniProt Consortium]