Anti-Astrin/MAP126

Anti-Astrin/MAP126
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A301-511A-T 10 µl (10 µg) -

3 - 9 Werktage

125,00 €
A301-511A 100 µl (100 µg) -

3 - 9 Werktage

443,00 €
 
Protein function: Essential component of the mitotic spindle required for normal chromosome... mehr
Produktinformationen "Anti-Astrin/MAP126"
Protein function: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). [The UniProt Consortium]
Schlagworte: Anti-SPAG5, Anti-Astrin, Anti-MAP126, Anti-Deepest, Anti-Sperm-associated antigen 5, Anti-Mitotic spindle-associated protein p126
Hersteller: Bethyl Laboratories
Hersteller-Nr: A301-511A-T

Eigenschaften

Anwendung: IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Pig, Gorilla, Chimpanzee, Crab-eating Macaque)
Immunogen: synthetic peptide. The epitope recognized by A301-511A-T maps to a region between residue 1 and 50 of human astrin (mitotic spindle associated protein p126) using the numbering given in entry NP_006452.3 (GeneID 10615).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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