Anti-AP3B1

Protein function: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [The UniProt Consortium] Recommended dilutions: WB 1:1000-2000. Cellular localization: Cytoplasmic vesicle, clathrin-coated vesicle membrane , Peripheral membrane protein , Cytoplasmic side . Golgi apparatus . Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. .