Anti-ANAG

This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008], Protein function: Involved in the degradation of heparan sulfate. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Lysosome.