Anti-alpha-Cardiac Actin (N-Term) Rabbit Monoclonal Antibody (Clone RM257)

alpha-Cardiac actin is one of the main actin isoforms found in adult cardiac muscle and the predominant actin in the embryonic heart. It is a globular protein that forms microfilaments at the Z-disc of sarcomeres and interacts with myosin to perform myofilament, and thus cardiac muscle, contractions. Knockout of Actc1, the gene encoding alpha-cardiac actin, is embryonic lethal in approximately half of mice and generally lethal within two weeks of birth for the other 50%. Mutations in ACTC1 are associated with atrial septal defects, familial hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy. Cayman's alpha-Cardiac Actin (N-Term) Rabbit Monoclonal Antibody (Clone RM257) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: ACTC1, Actin, alpha Cardiac Muscle 1. Immunogen: Synthetic peptide corresponding to the N-terminal region of human alpha-cardiac actin. Clone Designation: RM257. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Human alpha-cardiac actin, (+) Mouse alpha-cardiac actin.