Anti-ADNP (Activity Dependent Neuroprotective Protein)

The activity-dependent neuroprotective protein (ADNP) gene is frequently ampli?ed in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. hADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. hADNP is implicated in maintaining cell survival, perhaps through modulation of p53. ADNP is a member of the protein family with a nine-zinc finger motif followed by a homeobox domain. The human ADNP (hADNP) mRNA is expressed in distinct normal tissues, while high expression levels are encountered in malignant cells. The hADNP gene is mapped to chromosome 20q12-13.2, a region amplified in neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. Inhibition of ADNP protein expression by antisense oligodeoxynucleotides results in reduction of cellular metabolic activity and increase in the tumor suppressor p53. Such results may suggest development of antisense ADNP oligodeoxynucleotides in antitumor therapeutics, Applications: Western Blot: 1:250-1:500, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.