Anti-Activin Receptor Type IIA (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRI

Activin isoforms and other members of the TGF-B superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActRI(A), ActRIB, ActRII(A) and ActRIIB, have been cloned from mammals. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% aa sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10uL labels 10e6 K562 human chronic myelogenous leukemia cell line., Optimal dilutions to be determined by the researcher. Excitation: 620-650nm , Emission: 660-670nm, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.