Anti-Actin, Smooth Muscle Specific, clone 1A4

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Actin is a major component of the cytoskeleton and is present in most cell types. This antibody is highly specific to actin from smooth muscles. Its epitope lies in the first four N-terminal amino acids. This antibody does not stain cardiac or skeletal muscle, however, it does stain myofibroblasts and myoepithelial cells. It could be used together with antimuscle specific actin and myogenin in making a diagnosis of smooth/skeletal muscle tumors. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas antimuscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with antimuscle specific actin and are negative with anti-myogenin. Protein function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [The UniProt Consortium]