Anti-ACKR2

Anti-ACKR2
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA073493.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA073493.100 100 µl -

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363,00 €
 
Protein function: Atypical chemokine receptor that controls chemokine levels and localization via... mehr
Produktinformationen "Anti-ACKR2"
Protein function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta- arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 54% and to rat: 56%
Schlagworte: Anti-ACKR2, Anti-CCBP2, Anti-Chemokine receptor CCR-9, Anti-Chemokine receptor CCR-10, Anti-C-C chemokine receptor D6, Anti-Chemokine-binding protein 2, Anti-Chemokine-binding protein D6, Anti-Atypical chemokine receptor 2
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA073493

Eigenschaften

Anwendung: ICC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP (ATA-APrEST93151)

Datenbank Information

KEGG ID : K04187 | Passende Produkte
UniProt ID : O00590 | Passende Produkte
Gene ID : GeneID 1238 | Passende Produkte
Protein Atlas Nr. : ENSG00000144648

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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