Anti-ABIN3

Anti-ABIN3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ABIN3 from other sources has not been determined. Protein function: Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. [The UniProt Consortium]