Products from Chimerigen Laboratories
Chimerigen develops and manufactures unique, immunoglobulin-based, chimeric fusion proteins and related research products using advanced cellular and molecular biological techniques. These reagents are used successfully in basic biomedical and applied research.
More information at: www.adipogen.com/chimerigen
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CD137 (human):Fc (human) (rec.)
Item number: CHI-HF-210CD137-C100
Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells....
| Keywords: | CD137, CDw137, TNFRSF9, T-cell antigen ILA, 4-1BB ligand receptor, T-cell antigen 4-1BB homolog, Tumor necrosis factor... |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
429.00€
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CD27 (human):Fc (human) (rec.)
Item number: CHI-HF-210CD27-C100
The extracellular domain of human CD27 (aa 21-192) is fused to the N-terminus of the Fc region of human IgG1. CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and...
| Keywords: | T14, CD27, TNFRSF7, CD27 antigen, CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor... |
| Application: | Inhibitor the proliferation of T cells induced by CD27 ligand and anti-CD3. |
| Expressed in: | Hamster cells |
| Origin: | human |
418.00€
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CD272 [BTLA] (human):Fc (human) (rec.)
Item number: CHI-HF-210CD272-C100
BTLA is a type I transmembrane glycoprotein of the CD28 family of T cell costimulatory molecules. BTLA functions as a coinhibitor on activated T cells and on B cells and dendritic cells. The extracellular domain (ECD) of this Ig superfamily protein contains one V-type Ig-like domain, which interacts with HVEM.
| Keywords: | BTLA, CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, BTLA, B- and T-lymphocyte attenuator |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
429.00€
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CD28 (human):Fc (human) (rec.)
Item number: CHI-HF-210CD28-C200
The extracellular domain of human CD28 (aa 19-152) is fused to the N-terminus of the Fc region of human IgG1. CD28 and CTLA-4 together with their ligands, CD80 (B7-1) and CD86 (B7-2), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally...
| Keywords: | TP44, CD28, T-cell-specific surface glycoprotein CD28 |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
484.00€
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CD40 (human):Fc (human) (rec.)
Item number: CHI-HF-210CD40-C100
The extracellular domain of human CD40 (aa 21-193) is fused to the N-terminus of the Fc region of human IgG1. CD40 protein function: Receptor for TNFSF5/CD40LG. [The UniProt Consortium] CD40 [TNFRSF5] is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and play an...
| Keywords: | Bp50, CD40, CDw40, TNFRSF5, CD40L receptor, B-cell surface antigen CD40, Tumor necrosis factor receptor superfamily member 5 |
| Application: | Binding assays |
| Expressed in: | Hamster cells |
| Origin: | human |
523.00€
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CD40L [CD154] (human):Fc (human) (rec.)
Item number: CHI-HF-210CD40L-C050
The extracellular domain of human CD40L [CD154] (aa 113-261) is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein that belongs to...
| Keywords: | TRAP, CD40L, CD154, CD40LG, CD40-L, CD40 ligand, T-cell antigen Gp39, CD40 ligand, soluble form, CD40 ligand, membrane... |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
380.00€
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CD68 (human):Fc (human) (rec.)
Item number: CHI-HF-210CD68-C100
The extracellular domain of human CD68 (aa 22-319) is fused to the N-terminus of the Fc region of human IgG1. CD68 protein function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to...
| Keywords: | CD68, Gp110, Macrosialin |
| Application: | Binding assays |
| Expressed in: | Hamster cells |
| Origin: | human |
600.00€
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CD80 (human):Fc (human) (rec.)
Item number: CHI-HF-210CD80-C100
The extracellular domain of human CD80 (aa 35-242) is fused to the N-terminus of the Fc region of human IgG1. CD80 (B7-1) and CD86 (B7-2) together with their receptors CD28 and CTLA-4 constitute one of the dominant costimulatory pathways that regulate T cell and B cell responses. Although both CTLA-4 and CD28 can...
| Keywords: | B7, BB1, CD80, CD28LG, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80 |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
429.00€
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DcR3 (human):Fc (human) (rec.)
Item number: CHI-HF-210DcR3-C100
The extracellular domain of human DcR3 (aa 24-300) is fused to the N-terminus of the Fc region of human IgG1. DcR3 protein function: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. [The UniProt Consortium] Decoy receptor 3 (DcR3, TNFRSF6B,...
| Keywords: | M68, DcR3, DCR3, TNFRSF6B, Decoy receptor 3, Decoy receptor for Fas ligand, Tumor necrosis factor receptor superfamily... |
| Expressed in: | Hamster cells |
| Origin: | human |
457.00€
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EGF (human): Fc (human) (rec.)
Item number: CHI-HF-210EGF-C100
Unfortunately, most cytokines have short circulating half-lives. With the creation of a group of new immunoglobulin- based cytokine fusion proteins, in which a cytokine sequence had been genetically fused to the hinge, CH2 and CH3 regions of an immunoglobulin, these cytokine fusion proteins possess both the...
| Keywords: | EGF, Urogastrone, Epidermal growth factor |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
237.00€
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Fc (human) IgG4 Control (rec.)
Item number: CHI-HF-210IG4-C100
This product should be used as the control protein for activity tests of fusion proteins including human target proteins and human IgG-Fc domains.
| Keywords: | IGHG4, Ig gamma-4 chain C region, |
| Application: | Bioassays |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | ~32 kD |
391.00€
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CD273 [PD-L2] (human):Fc (human) (rec.)
Item number: CHI-HF-210PDL2-C100
The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of human IgG1. T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273...
| Keywords: | B7DC, PD-L2, CD273, B7-DC, PDCD1LG2, PD-1 ligand 2, PDCD1 ligand 2, Butyrophilin B7-DC, Programmed death ligand 2,... |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
429.00€
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