Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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Doxorubicin (hydrochloride)
Item number: Cay15007-5
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...
| Keywords: | DOX,... |
| Application: | DNA topoisomerase II inhibitor, antitumor agent |
| CAS | 25316-40-9 |
| MW: | 580 D |
From 60.00€
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DPP (IV) Inhibitor Screening Assay Kit
Item number: Cay700210-96
DPP (IV) inhibitors have emerged as a new class of oral antidiabetic agents. These inhibitors promote glucose homeostasis by inhibiting degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by DPP (IV). GLP-1 extends the action of insulin while suppressing the release...
| Keywords: | Dipeptidyl peptidase IV |
| Application: | DPP (IV) inhibitor screening |
| Species reactivity: | human |
609.00€
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SU 5416
Item number: Cay13342-50
SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2, FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 µM), SU 5416 also inhibits PDGFR (IC50 = 20 µM),...
| Keywords: | NSC 696819, Semaxinib, Sugen 5416, VEGFR 2 Kinase Inhibitor,... |
| Application: | Tyrosine kinase inhibitor |
| CAS | 204005-46-9 |
| MW: | 238.3 D |
From 198.00€
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LY294002
Item number: Cay70920-5
LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta...
| Keywords: | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| Application: | PI3K inhibitor |
| CAS | 154447-36-6 |
| MW: | 307.3 D |
From 44.00€
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Fumonisin B1
Item number: Cay62580-5
Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces...
| Keywords: | FB1, (2R,2'R)-1,2,3-propanetricarboxylic acid,... |
| Application: | Ceramide synthase inhibitor |
| CAS | 116355-83-0 |
| MW: | 721.8 D |
From 120.00€
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15-deoxy-Delta12,14-Prostaglandin J2
Item number: Cay18570-1
15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating...
| Keywords: | 15-deoxy-Delta12,14-PGJ2, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 87893-55-8 |
| MW: | 316.4 D |
From 55.00€
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SAHA
Item number: Cay10009929-100
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name:...
| Keywords: | Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide |
| Application: | HDAC inhibitor |
| CAS | 149647-78-9 |
| MW: | 264.3 D |
From 74.00€
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Erastin
Item number: Cay17754-5
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
| Keywords: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
| Application: | Antitumor agent |
| CAS | 571203-78-6 |
| MW: | 547.1 D |
From 76.00€
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Genipin
Item number: Cay10010622-25
Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion. High levels of UCP2 expression can disrupt pancreatic beta cell function and downregulate insulin secretion thereby contributing to the...
| Keywords: | (+)-Genipin, 1R,4aS,5,7aS-tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic acid, methyl ester |
| Application: | UCP2 inhibitor |
| CAS | 6902-77-8 |
| MW: | 226.2 D |
From 29.00€
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Protein Synthesis Assay Kit
Item number: Cay601100-96
Cayman's Protein Synthesis Assay Kit is a non-radioactive method for measuring protein synthesis that employs the cell-permeable, alkyne-containing, puromycin analog O-Propargyl-puromycin (OPP). Upon application to cells, the OPP probe incorporates into the C-terminus of translating polypeptide chains, thereby...
| Application: | FC, fluorescence |
549.00€
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Lipoxin A4
Item number: Cay90410-25
Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Cay-34700) or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (Cay-20110) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several...
| Keywords: | 5(S),6(R),15(S)-TriHETE, LXA4, 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 89663-86-5 |
| MW: | 352.5 D |
From 319.00€
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n-Dodecyl-beta-D-maltoside
Item number: Cay16494-5
n-Dodecyl-beta-D-maltoside (DDM) is a non-ionic detergent commonly used to solubilize membrane-associated proteins. In particular, it helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation. The critical micelle...
| Keywords: | DDM, Dodecyl Maltoside, dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside |
| Application: | Non-ionic detergent |
| CAS | 69227-93-6 |
| MW: | 510.6 D |
From 98.00€
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