Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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UltraPure Water
Item number: Cay400000-1
Formula Weight: 18.0.
| Keywords: | H2O, Hydrogen monoxide |
| MW: | 18 D |
From 40.00€
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(±)5(6)-EET
Item number: Cay50211-50
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior...
| Keywords: | (±)5,6-EpETrE, (±)5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| CAS | 87173-80-6 |
| MW: | 320.5 D |
From 70.00€
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(±)8(9)-EET
Item number: Cay50351-50
(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010). (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARalpha in HEK293 cells when used at a concentration of 1 µM but inhibits NF-kappaB activity induced by...
| Keywords: | (±)8,9-EpETrE, (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| MW: | 320.5 D |
From 60.00€
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Lipid-based Drug Delivery Tools
Sphingosine-1-phosphate (d18:1)
Item number: Cay62570-1
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...
| Keywords: | S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate) |
| Application: | Bioactive lipid assays |
| CAS | 26993-30-6 |
| MW: | 379.5 D |
From 122.00€
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L-NIL (hydrochloride)
Item number: Cay80310-10
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection...
| Keywords: | N6-(1-iminoethyl)-L-lysine, dihydrochloride |
| Application: | iNOS inhibitor |
| CAS | 159190-45-1 |
| MW: | 260.2 D |
From 85.00€
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DETA NONOate
Item number: Cay82120-10
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.Formal Name:...
| Keywords: | Diethylenetriamine NONOate, NOC-18, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate |
| Application: | NO donor |
| CAS | 146724-94-9 |
| MW: | 163.2 D |
From 60.00€
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Disuccinimidyl Sulfoxide
Item number: Cay9002863-50
Disuccinimidyl sulfoxide (DSSO) is a protein cross-linking probe designed to be used with mass spectrometry (MS). It contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns. The...
| Keywords: | DSSO, 3,3'-sulfinylbis-propanoic acid, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester |
| Application: | Protein cross-linking probe |
| CAS | 1351828-03-9 |
| MW: | 388.3 D |
From 76.00€
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Ionomycin
Item number: Cay10004974-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Keywords: | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro... |
| Application: | Ca Ionophore |
| CAS | 56092-81-0 |
| MW: | 709 D |
From 76.00€
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Prostaglandin D2
Item number: Cay12010-1
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via...
| Keywords: | PGD2, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 41598-07-6 |
| MW: | 352.5 D |
From 85.00€
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PF-8380
Item number: Cay12018-25
Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay), the enzyme that converts lysophosphatidylcholine to lysophosphatidic acid...
| Keywords: | 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid |
| Application: | Autotaxin Inhibitor |
| CAS | 1144035-53-9 |
| MW: | 478.3 D |
From 74.00€
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SB-431542 (hydrate)
Item number: Cay13031-10
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
| Keywords: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
| Application: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| MW: | 384.4 D |
From 55.00€
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Compound E
Item number: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
| Keywords: | gamma-Secretase Inhibitor XXI,... |
| Application: | gamma-Secretase inhibitor |
| CAS | 209986-17-4 |
| MW: | 490.5 D |
From 290.00€
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