Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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Tamoxifen
Item number: Cay13258-1
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Keywords: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Application: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
From 101.00€
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15-keto Prostaglandin E1
Item number: Cay13680-1
15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.Formal Name: (11alpha,13E)-11-hydroxy-9,15-dioxo-prost-13-en-1-oic acid. CAS Number: 22973-19-9. Synonyms: 15-keto PGE1. Molecular Formula: C20H32O5. Formula Weight: 352.5....
| Keywords: | 15-keto PGE1, 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 22973-19-9 |
| MW: | 352.5 D |
From 101.00€
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Prostaglandin I2 (sodium salt)
Item number: Cay18220-1
Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto...
| Keywords: | Epoprostenol, PGI2, Prostacyclin, 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt |
| Application: | Bioactive lipid assays |
| CAS | 61849-14-7 |
| MW: | 374.5 D |
From 122.00€
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(±)11(12)-EET
Item number: Cay50511-50
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET...
| Keywords: | (±)11,12-EpETrE, (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| CAS | 87173-81-7 |
| MW: | 320.5 D |
From 91.00€
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Docosahexaenoic Acid
Item number: Cay90310-50
Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils. It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes. DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from...
| Keywords: | Cervonic Acid, DHA, 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid |
| Application: | Bioactive lipid studies |
| CAS | 6217-54-5 |
| MW: | 328.5 D |
From 76.00€
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Latrunculin A
Item number: Cay10010630-100
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can...
| Keywords: | NSC 613011,... |
| Application: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421.6 D |
From 85.00€
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Bafilomycin A1
Item number: Cay11038-1
Bafilomycin A1 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases, Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases....
| Keywords: | NSC 381866,... |
| Application: | V-ATPase inhibitor |
| CAS | 88899-55-2 |
| MW: | 622.8 D |
From 153.00€
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Metformin (hydrochloride)
Item number: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
| Keywords: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Application: | AMPK activator |
| CAS | 1115-70-4 |
| MW: | 165.6 D |
From 45.00€
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Hygromycin B (hydrate)
Item number: Cay14291-1
Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 µg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for...
| Keywords: | O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N3-methyl-D-strep... |
| Application: | Antibiotic |
| MW: | 527.5 D |
From 135.00€
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FCCP
Item number: Cay15218-10
FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 µM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the...
| Keywords: | Trifluoromethoxy carbonylcyanide phenylhydrazone, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile |
| Application: | Inhibits mitochondrial oxidative phosphorylation, uncoupling reagent |
| CAS | 370-86-5 |
| MW: | 254.2 D |
From 112.00€
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Ganglioside GT1b (bovine) (sodium salt)
Item number: Cay15588-5
Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 µM, respectively. Ganglioside GT1b-containing...
| Keywords: | Ganglioside G1 Mixture |
| Application: | Trisialoganglioside |
| MW: | 2126.3 D |
From 198.00€
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Leukotriene B4
Item number: Cay20110-25
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar...
| Keywords: | LTB4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 71160-24-2 |
| MW: | 336.5 D |
From 229.00€
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