Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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VPS34-IN-19
Item number: Cay41357-10
An inhibitor of VPS34 (IC50 = 15 nM), selective for VPS34 over PI3Kdelta (IC50 = 802 nM) and PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >802 nM for all), increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per...
| Keywords: | Compound 19, Vacuolar Protein Sorting 34 Inhibitor 19, VPS Inhibitor 19,... |
| Application: | VPS34 inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.5 D |
From 147.00€
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MSD-M1PAM
Item number: Cay41358-1
A positive allosteric modulator of M1 mAChRs, enhances ACh-induced calcium production in a calcium mobilization assay from 0.1-10 µM, reverses scopolamine-induced deficits in freezing behavior in mice from 1-30 mg/kg, attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object...
| Keywords: | PQCA, 1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid |
| Application: | Muscarinic acetylcholine receptor M1 positive allosteric modulator |
| CAS | 1144504-35-7 |
| MW: | 388.4 D |
From 80.00€
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O12-D3-I3
Item number: Cay41385-1
An ionizable cationic lipid (pKa = 6.39), has been used in the generation of LNPs for siRNA delivery in vitro and in vivo, LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells, LNPs containing O12-D3-I3 and an...
| Keywords: | didodecyl 3,3'-((3-(2-amino-3-(1H-imidazol-4-yl)propanamido)propyl)azanediyl)dipropionate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 692.03 D |
From 60.00€
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Dovitinib (lactate)
Item number: Cay41394-1
A multi-kinase inhibitor, inhibits FLT3, CSF1R, c-Kit, FGFR1, FGFR3, VEGFR1, -2, and -3, PDFGRalpha, and PDGFRbeta (IC50s = 1, 36, 2, 8, 9, 10, 13, 8, 27, and 210 nM, respectively), inhibits the proliferation of human multiple myeloma cell lines expressing mutant, but not wild-type, FGFR3 (IC50s = 90-550 and >2,500...
| Keywords: | CHIR258, TKI-258, 2-hydroxy-propanoic acid, compd. with... |
| Application: | Multi-kinase inhibitor |
| CAS | 852433-84-2 |
| MW: | 572.59 D |
From 45.00€
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ML-401
Item number: Cay41450-10
An EBI2 antagonist (IC50 = 1.03 nM), inhibits RS11846 cell chemotaxis (IC50 = 4.533 nM). Formulation: A solid. InChI: InChI=1S/C20H20BrClN2O/c21-18-6-1-16(2-7-18)5-10-20(25)24-13-11-23(12-14-24)15-17-3-8-19(22)9-4-17/h1-10H,11-15H2/b10-5+. InChIKey: NXTNVQJKGHAGAX-BJMVGYQFSA-N. SMILES:...
| Keywords: | (2E)-3-(4-bromophenyl)-1-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-propen-1-one |
| Application: | EBI2 antagonist |
| CAS | 1597489-14-9 |
| MW: | 419.74 D |
From 116.00€
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ACTH (7-38) (human) (trifluoroacetate salt)
Item number: Cay41547-1
A peptide fragment of ACTH and an antagonist of MC2R, inhibits ACTH-induced corticosterone production in isolated rat adrenal cells at 0.455 or 4.55 µM, inhibits ACE1 (IC50 = 750 nM for the dog enzyme), inhibits basal cAMP secretion by isolated rat inner adrenocortical cells at 1 µM, induces hypotension in...
| Keywords: | Adrenocorticotropic Hormone (7-38), CIP, Corticotropin Inhibitory Peptide, alpha7-38-ACTH, 31-L-serine-a7-38-corticotropin... |
| Application: | ACTH peptide fragment, MC2R antagonist |
| MW: | 3659.2 D |
From 67.00€
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PG-931
Item number: Cay41551-1
A peptide MC4R agonist, increases intracellular cAMP levels in CHO cells expressing MC4R (EC50 = 0.42 nM), selectively binds to MC4R over MC3R and MC5R (IC50s = 0.58, 55, and 2.4 nM, respectively), increases MAP, pulse pressure, and respiratory rate in a rat model of hemorrhagic shock in a dose-dependent manner and...
| Keywords: | Ac-Nle-cyclic[Asp-Pro-D-Phe-Arg-Trp-Lys]-Pro-Val-NH2, (2?7)-lactam... |
| Application: | Peptide MC4R agonist |
| CAS | 667430-81-1 |
| MW: | 1180.4 D |
From 55.00€
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Isoleucine
Item number: Cay41562-50
A mixture of isoleucine diastereomers. Formulation: A solid. InChI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9). InChIKey: AGPKZVBTJJNPAG-UHFFFAOYSA-N. SMILES: CCC(C)C(N)C(O)=O
| Keywords: | 2-amino-3-methyl-pentanoic acid |
| Application: | Isoleucine diastereomer mixture |
| CAS | 2095501-92-9 |
| MW: | 131.2 D |
55.00€
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Fenoprofen-13C6 (sodium salt hydrate)
Item number: Cay41683-1
An internal standard for the quantification of fenoprofen by GC- or LC-MS. Formulation: A solid. InChI: InChI=1S/C15H14O3.Na.H2O/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13,,/h2-11H,1H3,(H,16,17),,1H2/q,+1,/p-1/i2+1,3+1,4+1,7+1,8+1,13+1,,. InChIKey: MUQAHZSOOWLDJC-UWTURDRMSA-M. SMILES:...
| Keywords: | a-methyl-3-(phenoxy-1,2,3,4,5,6-13C6)-benzeneacetic acid, monosodium salt, hydrate |
| Application: | GC-MS, LC-MS, internal standard, quantification, NSAID |
| CAS | 2687960-29-6 |
| MW: | 270.2 D |
809.00€
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CP-EPS8-NLS (trifluoroacetate salt)
Item number: Cay41743-1
A cell-penetrating peptide inhibitor of EPS8 nuclear translocation, induces apoptosis and cell cycle arrest in the G0/G1 phase in THP-1, HL-60, and U937 cells at 70 µM, reduces phosphorylated ERK, STAT3, and Akt levels in THP-1, HL-60, and U937 cells at 35 or 70 µM, reduces tumor volume without affecting body weight...
| Keywords: | CP-Epidermal Growth Factor Receptor Kinase Substrate 8-NLS |
| Application: | Cell-penetrating EPS8 nuclear translocation peptide inhibitor |
| MW: | 3227.88 D |
From 70.00€
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GSK3685032
Item number: Cay41882-1
A DNMT1 inhibitor (IC50 = 0.23 µM), selective for DNMT1 over DNMT3A/3L and DNMT3B/3L and a panel of 34 methyltransferases and 369 kinases (IC50s = >10 µM for all), inhibits the proliferation of 51 hematological cancer cell lines (median IC50 = 0.64 µM), decreases overall DNA methylation and gene expression in...
| Keywords: | aR-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-benzeneacetamide |
| Application: | DNMT1 inhibitor |
| CAS | 2170140-50-6 |
| MW: | 420.54 D |
From 104.00€
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Santalol
Item number: Cay41891-100
A mixture of alpha-santalol and beta-santalol. Formulation: A neat oil. InChI: InChI=1S/2C15H24O/c1-10(9-16)5-4-6-14(2)11-7-12-13(8-11)15(12,14)3,1-11(10-16)5-4-8-15(3)12(2)13-6-7-14(15)9-13/h5,11-13,16H,4,6-9H2,1-3H3,5,13-14,16H,2,4,6-10H2,1,3H3/b10-5-,11-5-/t11?,12-,13?,14+,15?,13-,14+,15+/m01/s1. InChIKey:...
| Application: | Sesquiterpenoids, alpha-santalol/beta-santalol mixture |
| CAS | 11031-45-1 |
| MW: | 220.4 D |
From 45.00€
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