Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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Perfluorohexyloctane
Item number: Cay40490-1
A semifluorinated alkane and PFAS, improves corneal penetration of cyclosporine A in porcine eyes ex vivo at 0.05 and 0.1%, topical application improves the lipid layer grade in rabbit eyes in vivo without inducing irritation. Formulation: A solid. InChI:...
| Keywords: | 1-(Perfluorohexyl)octane, F6H8, NOV03, 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-tetradecane |
| Application: | Semifluorinated alkane, PFAS |
| CAS | 133331-77-8 |
| MW: | 432.26 D |
376.00€
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BSJ-04-132
Item number: Cay41248-1
A PROTAC that drives Cdk4 degradation, selectively induces the degradation of Cdk4 over Cdk6, IKZF1, and IKZF3 in a cereblon-dependent manner in Jurkat cells at 1 µM. Formulation: A solid. InChI:...
| Keywords: | 7-cyclopentyl-2-[[5-[4-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]... |
| Application: | Cdk4 degradation driving PROTAC |
| CAS | 2349356392 |
| MW: | 819.9 D |
From 178.00€
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DMT7
Item number: Cay41389-1
An ionizable cationic lipid (pKa = 6.5), has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo, LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast...
| Keywords: | 1-(2-(dimethylamino)ethyl)-3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl)thiourea |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 658.2 D |
From 105.00€
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Cell-free Protein Synthesis (E. coli) Kit
Item number: Cay41534-1
Cell-free protein synthesis (CFPS) is an easy-to-use, rapid, and efficient system that is devoid of membrane-bound barriers but contains the native cellular transcriptional and translational machinery and exogenous resources (e.g., amino acids, nucleotides, and a secondary energy substrate) needed for synthesis of...
| Keywords: | CFPS |
| Application: | Cell-free protein synthesis |
345.00€
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E17241
Item number: Cay41675-1
An inducer of ABCA1 expression, induces the expression of ABCA1 in a reporter assay using HepG2 cells (EC50 = 280 nM), an agonist of PPARs, induces PPAR-mediated gene expression in reporter assays using HepG2 cells expressing PPARgamma, PPARalpha, or PPARdelta (EC50s = 290, 3,900, and 879 nM, respectively),...
| Keywords: | 4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide, 4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide |
| Application: | ABCA1 expression inducer |
| CAS | 1060968-92-4 |
| MW: | 318.4 D |
From 70.00€
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Werner Syndrome RecQ Helicase-IN-2
Item number: Cay41678-1
An inhibitor of WRN (IC50 = 100 nM), selectively inhibits the growth of SW48 cells over DLD-1-WRN-KO cells (GI50s = 100 and >10,000 nM, respectively), reduces tumor volume in an SW48 mouse xenograft model at 120 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Werner Syndrome RecQ Helicase Inhibitor 2, WS RecQ Helicase Inhibitor 2, WS RecQ Helicase-IN-2,... |
| Application: | WRN inhibitor |
| CAS | 2869954-51-6 |
| MW: | 681.7 D |
From 153.00€
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Lipid A
Item number: Cay41708-1
An ionizable cationic lipid (pKa = 4.67). Formulation: A solution in ethanol. InChI: InChI=1S/C48H95NO5/c1-6-11-15-19-21-29-37-44(35-27-17-13-8-3)47(51)53-41-33-25-23-31-39-49(46(10-5)43-50)40-32-24-26-34-42-54-48(52)45(36-28-18-14-9-4)38-30-22-20-16-12-7-2/h44-46,50H,6-43H2,1-5H3. InChIKey:...
| Keywords: | 2-hexyl-decanoic acid, 1,1'-[[[1-(hydroxymethyl)propyl]imino]di-6,1-hexanediyl] ester |
| Application: | Ionizable cationic lipid |
| CAS | 2036273-20-6 |
| MW: | 766.27 D |
From 120.00€
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DC-U4106
Item number: Cay41723-1
A USP8 inhibitor (IC50 = 1.2 µM), selective for USP8 over USP2 and USP7 (IC50s = 58.4 and >100 µM, respectively), induces apoptosis in, and inhibits colony formation by, MCF-7 cells from 1-5 µM, reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg. Formulation: A solid. InChI:...
| Keywords: | 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-4H-1-benzopyran-4-one |
| Application: | USP8 inhibitor |
| CAS | 2410534-62-0 |
| MW: | 525.6 D |
From 223.00€
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Spongosine
Item number: Cay41832-1
A nucleoside with diverse biological activities, antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors), inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM, decreases...
| Keywords: | 2-Methoxyadenosine, NSC 36899, 2-methoxy-adenosine |
| Application: | Bioactive nucleoside |
| CAS | 24723-77-1 |
| MW: | 297.3 D |
From 76.00€
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MMV390048
Item number: Cay41835-10
A P. vivax PI4K inhibitor (IC50 = 3.4 nM), active against P. falciparum (IC50 = 28 nM), decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg), reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys at 20...
| Keywords: | 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
| Application: | Plasmodium vivax PI4K inhibitor |
| CAS | 1314883-11-8 |
| MW: | 393.4 D |
From 107.00€
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AQW-051
Item number: Cay41851-10
A partial agonist of the alpha7 nAChR, induces calcium influx in GH3 cells expressing alpha7 nAChR (EC50 = 38.9 nM), improves learning and memory in the social recognition test in mice at 0.03 or 0.3 mg/kg, improves learning and memory in the Morris water maze test in rats at 3 mg/kg, increases the duration of...
| Keywords: | VQW-765, (3R)-3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-1-azabicyclo[2.2.2]octane |
| Application: | alpha7 nAChR partial agonist |
| CAS | 669770-29-0 |
| MW: | 294.4 D |
From 104.00€
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DBCO acid
Item number: Cay41894-1
A copper-free click chemistry reagent, has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro, has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to...
| Keywords: | Dibenzocyclooctyne Acid, 11,12-didehydro-?-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid |
| Application: | Copper-free click chemistry reagent |
| CAS | 1353016-70-2 |
| MW: | 305.33 D |
From 43.00€
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