Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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Paltusotine
Item number: Cay42041-10
An SST2 agonist, selectively inhibits cAMP production in cells expressing SST2 over cells expressing SST1, SST3, SST4, or SST5 (EC50s = 25, >1,000, >1,000, >1,000, and >1,000 nM, respectively), reduces GHRH-stimulated growth hormone release in rats at 3, 10, and 30 mg/kg, reduces plasma levels of IGF-1 in beagle...
| Keywords: | CRN00808, 3-[4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl]-2-hydroxy-benzonitrile |
| Application: | SST2 agonist |
| CAS | 2172870-89-0 |
| MW: | 456.5 D |
From 421.00€
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BI-87G3
Item number: Cay42045-1
A JNK1 inhibitor (IC50 = 1.804 µM), selective for JNK1 over p38alpha MAPK, Akt, furin, and lethal factor (IC50s = >100, >100, >100, and >50 µM, respectively), inhibits TNF-alpha-induced JNK1 phosphorylation in HeLa cells (IC50 = ~15 µM). Formulation: A solid. InChI:...
| Keywords: | c-Jun N-terminal Kinase Inhibitor XI, JNK Inhibitor XI, 2-[(5-nitro-2-thiazolyl)thio]-benzothiazole |
| Application: | JNK1 inhibitor |
| CAS | 2207-44-5 |
| MW: | 295.4 D |
From 40.00€
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KEA1-97
Item number: Cay42049-10
An inhibitor of the protein-protein interaction between Trx and caspase-3, binds to K72 of Trx and inhibits DCT-alkyne labeling of recombinant Trx (IC50 = 10 µM), inhibits the interaction between thioredoxin and caspase-3 in a cell-free assay at 100 µM, reduces survival and proliferation of and induces apoptosis in...
| Keywords: | 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine |
| Application: | Trx-caspase-3 protein-protein interaction inhibitor |
| CAS | 2138882-71-8 |
| MW: | 335.16 D |
From 70.00€
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CFT-7455
Item number: Cay42053-1
A cereblon ligand 1-containing degrader of IKZF1 and IKZF3, reduces levels of IKZF1 and IKZF3 in NCI H929 cells at 0.1 nM, decreases the growth of NCI H929 cells (GI50 = 0.0743 nM), reduces tumor volume in an RPMI-8226 plasmocytoma mouse xenograft model at 30 or 100 µg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Cemsidomide, 3S-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-2,6-piperidinedione |
| Application: | Cereblon ligand 1-containing IKZF1 / IKZF3 degrader |
| CAS | 2504235-67-8 |
| MW: | 469.53 D |
From 110.00€
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AZ 13705339
Item number: Cay42087-10
A PAK1 inhibitor (IC50 = 0.33 nM), selective for PAK1 over a panel of 117 kinases at 100 nM, binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively), inhibits S. enterica infection in HAP1 cells at 10 µM, inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils...
| Keywords: | 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylpheny... |
| Application: | PAK1 (p21-activated kinase 1) inhibitor |
| CAS | 2016806-57-6 |
| MW: | 629.8 D |
From 116.00€
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GAPDH Inhibitor Compound F8
Item number: Cay42090-1
A covalent inhibitor of GAPDH (IC50 = 39.31 µM), decreases viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner. Formulation: A solid. InChI: InChI=1S/C20H18N2O5/c1-3-13(7-15(5-1)23-9-17-11-25-17)19-21-22-20(27-19)14-4-2-6-16(8-14)24-10-18-12-26-18/h1-8,17-18H,9-12H2. InChIKey:...
| Keywords: | 2,5-bis[3-(2-oxiranylmethoxy)phenyl]-1,3,4-oxadiazole |
| Application: | GAPDH covalent inhibitor |
| CAS | 252212-58-1 |
| MW: | 366.37 D |
From 55.00€
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Martinostat
Item number: Cay42100-10
An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively), selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively), reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both)....
| Keywords: | N-hydroxy-3-[4-[[methyl(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]methyl]phenyl]-2E-propenamide |
| Application: | HDAC inhibitor |
| CAS | 1629052-58-9 |
| MW: | 354.5 D |
From 153.00€
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GSK467
Item number: Cay42103-1
A JARID1B inhibitor (IC50 = 0.02-0.1 µM), selective for JARID1B over KMD2, -3, -4, and -5 (IC50s = 1-10 µM). Formulation: A solid. InChI: InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23). InChIKey: ZTYRLXUTLYBVHH-UHFFFAOYSA-N. SMILES:...
| Keywords: | 2-[[1-(phenylmethyl)-1H-pyrazol-4-yl]oxy]- pyrido[3,4-d]pyrimidin-4(3H)-one |
| Application: | JARID1B (KDM5B) inhibitor |
| CAS | 1628332-52-4 |
| MW: | 319.3 D |
From 60.00€
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GSK3beta Inhibitor 1
Item number: Cay42107-10
A GSK3beta inhibitor (IC50 = 4.19 nM), decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-. InChIKey: YKQONSWBHGBDSB-XFXZXTDPSA-N....
| Keywords: | Glycogen Synthase Kinase 3beta Inhibitor I, (3Z)-1,3-dihydro-3-(2-pyridinylmethylene)-2H-indol-2-one |
| Application: | GSK3beta inhibitor |
| CAS | 187325-53-7 |
| MW: | 222.2 D |
From 223.00€
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A-425619
Item number: Cay42117-10
A TRPV1 antagonist, selective for TRPV1 over a panel of 83 receptors, enzymes, transporters, and ion channels at 10 µM, inhibits capsaicin-, NADA-, anandamide-, or acid-induced increases in intracellular calcium in HEK293 cells expressing human TRPV1 (IC50s = 5, 4, 3, and 2 nM, respectively), increases core body...
| Keywords: | N-5-isoquinolinyl-N'-[[4-(trifluoromethyl)phenyl]methyl]-urea |
| Application: | TRPV1 antagonist |
| CAS | 581809-67-8 |
| MW: | 345.3 D |
From 208.00€
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D-Amino Acid Oxidase Inhibitor
Item number: Cay23894-100
An inhibitor of DAAO (IC50s = 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively), selective for DAAO over a panel of 150 enzymes, receptors and ion channels (30 µM), inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner (10-200 mg/kg, i.p.), increases levels...
| Keywords: | DAAO inhibitor, 4H-thieno[3,2-b]pyrrole-5-carboxylic acid |
| Application: | DAAO inhibitor |
| CAS | 39793-31-2 |
| MW: | 167.2 D |
From 40.00€
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Voacanga africana Ethanol Extract
Item number: Cay43250-1
A natural extract, contains a crude mixture of bioactive natural products extracted from V. africana. Formulation: A solution in methanol. InChI: . InChIKey: . SMILES:
| Keywords: | V. africana Ethanol Extract |
| Application: | Natural extract, crude mixture of bioactive natural products |
76.00€
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