Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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PIT
Item number: Cay45579-10
PIT is a negative allosteric modulator of the purinergic P2Y1 receptor. It selectively inhibits agonist-induced signaling for P2Y1 over P2Y2, P2Y4, and P2Y11 receptors in 1321N1 cells and the P2Y12 receptor in CHO cells at 10 µM. PIT inhibits ATP-induced relaxation of guinea pig taenia caeci preparations and reduces...
| Keywords: | 2,2'-Pyridylisatogen tosylate, 1-oxide 2-(2-pyridinyl)-3H-indol-3-one, 4-methylbenzenesulfonate |
| Application: | P2Y1 receptor negative allosteric modulator |
| CAS | 56583-49-4 |
| MW: | 396.42 D |
From 91.00€
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M2912
Item number: Cay45586-1
M2912 is an inhibitor of tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.6 and 0.9 nM, respectively). It is selective for TNKS1 and TNKS2 over poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 928 nM). M2912 increases the levels of Axin2 (EC50 = 17 nM) and reduces Wnt reporter activity in DLD-1 cells. It reduces the growth of a...
| Keywords: | MSC2504877, 3-[4-(1-hydroxy-1-methylethyl)phenyl]-6-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one |
| Application: | TNKS1/2 inhibitor |
| CAS | 1460286-21-8 |
| MW: | 282.34 D |
From 49.00€
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Mc-Ala-Ala-PAB
Item number: Cay45589-10
Mc-Ala-Ala-PAB is a peptide linker molecule that has been used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds. Mc-Ala-Ala-PAB has been used...
| Application: | Peptide linker molecule, ADC synthesis |
| CAS | 1949793-44-5 |
| MW: | 458.51 D |
From 49.00€
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Tripeptide-41 (acetate)
Item number: Cay45598-1
Tripeptide-41 is a cosmeceutical peptide.. SMILES: OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CC3=CNC4=CC=CC=C34)=O.OC(C)=O. InChi Code:...
| Keywords: | H-Phe-Trp-Tyr-OH, L-phenylalanyl-L-tryptophyl-L-tyrosine, acetate |
| Application: | Cosmeceutical peptide |
| MW: | 514.58 D |
From 55.00€
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Oligopeptide-20 (acetate)
Item number: Cay45612-1
Oligopeptide-20 is a peptide that corresponds to amino acids 55-66 of mature insulin-like growth factor 1 (IGF-1). It increases growth of keratinocytes and fibroblasts and the levels of procollagen, laminin, and fibronectin in keratinocytes. Oligopeptide-20 (100 mg/animal), as part of a peptide nanosome-based skin...
| Keywords: | L-arginyl-L-arginyl-L-leucyl-L-alpha-glutamyl-L-methionyl-L-tyrosyl-L-cysteinyl-L-alanyl-L-prolyl-L-leucyl-L-lysyl-L-proline |
| Application: | IGF-1-based peptide, cosmeceutical peptide |
| MW: | 1476.82 D |
From 49.00€
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Acetyl Hexapeptide-49 (trifluoroacetate salt)
Item number: Cay45626-10
Acetyl hexapeptide-49 is an antagonist of proteinase-activated receptor 2 (PAR2). It inhibits PAR2 agonist-induced calcium release and calcitonin gene-related peptide (CGRP) and IL-6 production in human keratinocytes. Acetyl hexapeptide-49 also induces proliferation in human keratinocytes and has photoprotective...
| Keywords: | Ac-Phe-Phe-Trp-Phe-His-Val-NH2,... |
| Application: | PAR2 antagonist |
| MW: | 923.1 D |
From 40.00€
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Diaminopropionyl Tripeptide-33 (acetate)
Item number: Cay45627-1
Diaminopropionyl tripeptide-33 is a peptide containing alanine, proline, and histidine and modified with a 2,3-diaminopropionyl (DAP) group.. SMILES: C[C@H](NC(C(N)CN)=O)C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CN=CN2)=O)=O.CC(O)=O. InChi Code:...
| Keywords: | DAP Tripeptide-33, H-Ala-Pro-His-OH, (2,3-diaminopropanoyl)-L-alanyl-L-prolyl-L-histidine, acetate |
| Application: | Photoprotective peptide |
| MW: | 409.45 D |
From 76.00€
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D-Pantothenic Acid-d4 (calcium salt)
Item number: Cay45632-1
D-Pantothenic acid-d4 is intended for use as an internal standard for the quantification of D-pantothenic acid (Cay-17288) by GC- or LC-MS. D-Pantothenic acid is the biologically active enantiomer of vitamin B5 and a biosynthetic precursor of coenzyme A (CoA). A D-pantothenic acid-deficient diet reduces food intake,...
| Keywords: | Vitamin B5-d4, (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate-2,2,3,3-d4, hemicalicum salt |
| Application: | GC-MS, LC-MS, internal standard, quantification, vitamin B5 enantiomer, coenzyme A |
| MW: | 484.6 D |
832.00€
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TMQ
Item number: Cay45640-1
TMQ is a tire rubber antioxidant. Topical application of TMQ increases the incidence of renal tubule adenoma and carcinoma in male rats and induces acanthosis and hyperkeratosis of the skin at the application site in male and female rats. It has been found in tire and road wear particles (TRWPs) from air and road...
| Keywords: | 2,2,4-Trimethyl-1,2-dihydroquinoline, NSC 4175, Polnox R, 1,2-dihydro-2,2,4-trimethyl-quinoline |
| Application: | Tire rubber antioxidant, toxicant |
| CAS | 147-47-7 |
| MW: | 173.26 D |
From 35.00€
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(4-Iodophenyl)boronic Acid
Item number: Cay45679-10
(4-Iodophenyl)boronic acid is an enhancer of luminol (Cay-16803) chemiluminescent peroxidation catalyzed by horseradish peroxidase (HRP). HRP-induced chemiluminescent light emission increases by >100-fold in the presence of (4-iodophenyl)boronic acid. (4-Iodophenyl)boronic acid has also been used as a fluorescent...
| Keywords: | 4-IPBA, B-(4-iodophenyl)-boronic acid |
| Application: | Chemiluminescence enhancer, HRP catalyzed luminol chemiluminescent peroxidation intensifier |
| CAS | 5122-99-6 |
| MW: | 247.83 D |
From 133.00€
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Kyotorphin (trifluoroacetate salt)
Item number: Cay45683-1
Kyotorphin is an endogenous analgesic neuropeptide found in mammalian brain and cerebrospinal fluid (CSF). It binds to the kyotorphin receptor with Kd values of 0.34 and 9.07 nM for the high- and low-affinity binding sites, respectively, in rat brain membranes. Kyotorphin (10 µM) induces the release of...
| Keywords: | Kiotorphin, KTP, L-Tyr-L-Arg-OH, Tyr-Arg-OH, L-tyrosyl-L-arginine |
| Application: | Endogenous analgesic neuropeptide |
| MW: | 337.38 D |
From 35.00€
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Hopantenate (calcium salt)
Item number: Cay45696-1
Hopantenate is a derivative of pantothenic acid (Cay-17288), a biosynthetic precursor of CoA. Hopantenate, after phosphorylation by pantothenate kinase (PanK), forms a nonreactive complex with phosphopantothenoylcysteine synthetase (PPCS) that inhibits cellular CoA biosynthesis. Hopantenate induces acute...
| Keywords: | HOPA, HoPan, 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]amino-butanoic acid, calcium salt |
| Application: | Pantothenic acid derivative |
| CAS | 17097-76-6 |
| MW: | 504.6 D |
From 35.00€
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