Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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Bleomycin (sulfate)
Item number: Cay13877-10
Bleomycin is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. Its mechanism of action causes single- and double-strand DNA breaks in tumor cells, which interrupts the cell cycle. Bleomycin is thought to achieve this by chelating metal ions, producing a pseudoenzyme that reacts with...
| Keywords: | Blenoxane, bleomycin sulfate (salt) |
| Application: | Apoptosis inducer |
| CAS | 9041-93-4 |
| MW: | 1415.6 D |
From 55.00€
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(+)-Etomoxir (sodium salt)
Item number: Cay11969-5
(+)-Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT1), an enzyme that combines fatty acyl-CoAs with carnitine for transport into the mitochondria for beta-oxidation. It inhibits fatty acid oxidation in hepatocytes in vitro (IC50s = 0.1, 1, and 10 µM for human, guinea pig, and rat...
| Keywords: | (R)-(+)-Etomoxir, (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid monosodium salt |
| Application: | Irreversible CPT1 / carnitine O-palmitoyltransferase 1 inhibitor |
| CAS | 828934-41-4 |
| MW: | 320.7 D |
From 122.00€
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S-Nitrosylated Protein Detection Kit (Biotin Switch)
Item number: Cay10006518-1
Nitric oxide (NO) is produced by three distinct isoforms of nitric oxide synthase and functions as a key signaling molecule in physiology and pathophysiology. NO transduces its effects by reacting either directly with heme and non-heme centers of proteins or indirectly via further oxidation to various reactive...
| Keywords: | S-NO |
| Application: | S-nitrosylated protein detection, WB |
590.00€
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Brefeldin A
Item number: Cay11861-5
Brefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. BFA directly and...
| Keywords: | Ascotoxin, BFA, Cyanein, Decumbin, Nectrolide, NSC 107456, NSC 244390, NSC 56310, NSC 89671, Synergisidin,... |
| Application: | Endosomal trafficking studies |
| CAS | 20350-15-6 |
| MW: | 280.4 D |
From 70.00€
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BAPTA AM
Item number: Cay15551-5
BAPTA (Cay-11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 µM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium...
| Keywords: | BAPTA Acetoxymethyl ester,... |
| Application: | Cell permeable calcium chelator |
| CAS | 126150-97-8 |
| MW: | 764.7 D |
From 59.00€
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8-Isoprostane Affinity Column
Item number: Cay401111-1
Cayman's 8-Isoprostane Affinity Column provides a specific and convenient means for the purification of 8-isoprostane (8-iso PGF2alpha) from urine and plasma samples. Each column contains 0.5 ml of affinity sorbent (mouse anti-8-isoprostane monoclonal antibody covalently bound to Sepharose 4).Formulation: 0.5 ml of...
| Keywords: | Cay400058-1 replacement. |
| Application: | Sample Preparation |
85.00€
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Acetoacetyl-Coenzyme A (sodium salt hydrate)
Item number: Cay21219-10
Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway. It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis. Acetoacetyl-CoA...
| Keywords: | Acetoacetyl-CoA, S-(3-oxobutanoate) coenzyme A, trisodium salt, tetrahydrate |
| Application: | HMG-CoA precursor |
| MW: | 989.6 D |
From 116.00€
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MLN4924
Item number: Cay15217-1
NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates with roles relevant to cellular processes important for cancer cell survival. Neddylation of CRLs is initiated...
| Keywords: | Pevonedistat, sulfamic acid,... |
| Application: | Adenosine 5'-monophosphate analog, NAE inhibitor |
| CAS | 905579-51-3 |
| MW: | 443.5 D |
From 82.00€
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16,16-dimethyl Prostaglandin E2
Item number: Cay14750-1
16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme. Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist on most EP receptor subtypes, and has been used experimentally to...
| Keywords: | 16,16-dimethyl PGE2, 9-oxo-11alpha,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid |
| Application: | PGDH inhibitor |
| CAS | 39746-25-3 |
| MW: | 380.5 D |
From 168.00€
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(2R)-Octyl-alpha-hydroxyglutarate
Item number: Cay16366-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Keywords: | (2R)-Octyl-2-HG, 2R-hydroxy-pentanedioic acid, 1-octyl ester |
| CAS | 1391194-67-4 |
| MW: | 260.3 D |
From 55.00€
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15(S)-HETE-d8
Item number: Cay334720-25
15(S)-HETE-d8 is intended for use as an internal standard for the quantification of 15(S)-HETE (Cay-34720) by GC- or LC-MS. (±)15-HETE and 15(S)-HETE are formed via non-enzymatic and 15-lipoxygenase-mediated oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607), respectively. 15(R)-HETE is formed by...
| Keywords: | 15(S)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| Application: | Standard |
| CAS | 84807-87-4 |
| MW: | 328.5 D |
From 273.00€
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Trichostatin A
Item number: Cay89730-1
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the...
| Keywords: | TSA, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide |
| Application: | HDAC inhibitor |
| CAS | 58880-19-6 |
| MW: | 302.4 D |
From 91.00€
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