Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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Tafluprost
Item number: Cay10005440-25
Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Cay-10005439) and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v. Ocular administration of tafluprost (0.0005% v/v)...
| Keywords: | AFP-168, 15,15-difluoro-9alpha,11alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl... |
| Application: | FP receptor agonist |
| CAS | 209860-87-7 |
| MW: | 452.5 D |
From 153.00€
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3-Deazaneplanocin A
Item number: Cay13828-1
3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells...
| Keywords: | DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
| Application: | S-adenosyl-L-homosysteine hydrolase inhibitor |
| CAS | 102052-95-9 |
| MW: | 262.3 D |
From 149.00€
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(2S)-Octyl-alpha-hydroxyglutarate
Item number: Cay16367-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Keywords: | (2S)-Octyl-2-HG, 2S-hydroxy-pentanedioic acid, 1-octyl ester |
| CAS | 1391194-64-1 |
| MW: | 260.3 D |
From 85.00€
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NEW
SLF
Item number: Cay10007974-100
FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation. Synthetic ligand of FKBP (SLF) is a...
| Keywords: | Synthetic Ligand of FKBP, 1-(3,3-dimethyl-1,2-dioxopentyl)-(2S)-2-piperidinecarboxylic acid,... |
| Application: | FK-506 analog |
| CAS | 195513-96-3 |
| MW: | 524.7 D |
1,371.00€
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NEW
Chk2 Inhibitor II
Item number: Cay17552-5
Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7. µM). This compound has been used to target the role of Chk2 in cellular signaling in...
| Keywords: | BML-277, C 3742, Checkpoint Kinase 2 Inhibitor II, 2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide |
| Application: | Checkpoint kinase 2 inhibitor |
| CAS | 516480-79-8 |
| MW: | 363.8 D |
From 144.00€
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L-Ascorbic Acid 2-phosphate (magnesium salt hydrate)
Item number: Cay16457-5
L-Ascorbic acid (vitamin C, Cay-14656) is essential for the synthesis of collagen, with deficiency resulting in scurvy. Notably, humans and other primates, guinea pigs, and certain other animals lack an enzyme necessary for vitamin C synthesis. L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid...
| Keywords: | AA2P, Ascorbyl PM, L-Ascorbic Acid 2-phosphate (magnesium salt), Phospitan C, 2-(dihydrogen phosphate)-L-ascorbic acid,... |
| Application: | Long-acting ascorbic acid derivative, collagen expression stimulator |
| CAS | 1713265-25-8 |
| MW: | 292.6 D |
From 116.00€
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PAF C-16
Item number: Cay60900-5
PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration, and the production of reactive oxygen species, and IL-6 in human macrophages. It is a more potent mediator of...
| Keywords: | Platelet-activating Factor C-16, 1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine |
| Application: | Bioactive lipid assays |
| CAS | 74389-68-7 |
| MW: | 523.7 D |
From 57.00€
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Staurosporine
Item number: Cay81590-1
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a...
| Keywords: | Stsp,... |
| Application: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466.5 D |
From 55.00€
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D-(+)-Glucose-13C6
Item number: Cay26707-1
D-(+)-Glucose-13C6 is intended for use as an internal standard for the quantification of D-(+)-glucose (Cay-23733) by GC- or LC-MS. D-(+)-Glucose is a monosaccharide that occurs in nature and is used by organisms as an energy source. D-(+)-Glucose is the more common enantiomer of L-(-)-glucose (Cay-20829).Formal...
| Keywords: | D-glucose-1,2,3,4,5,6-13C6 |
| Application: | GC-MS, LC-MS, internal standard, quantification |
| CAS | 110187-42-3 |
| MW: | 186.1 D |
From 85.00€
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Ferrostatin-1
Item number: Cay17729-5
Ferrostatin-1 is a ferroptosis inhibitor. It inhibits cell death induced by the ferroptosis inducers erastin (Cay-17754, EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 µM. Ferrostatin-1 (0.5 µM) inhibits erastin-induced...
| Keywords: | Fer-1, 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester |
| Application: | Ferroptosis inhibitor |
| CAS | 347174-05-4 |
| MW: | 262.4 D |
From 85.00€
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L-Leucyl-L-Leucine methyl ester (hydrochloride)
Item number: Cay16008-100
L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid...
| Keywords: | LLME, LLOMe, L-leucyl-L-leucine, methyl ester, monohydrochloride |
| Application: | Specific cytotoxin |
| CAS | 6491-83-4 |
| MW: | 294.8 D |
From 60.00€
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(+)-JQ1
Item number: Cay11187-5
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces...
| Keywords: | (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid,... |
| Application: | BRD4 inhibitor |
| CAS | 1268524-70-4 |
| MW: | 457 D |
From 44.00€
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