Products from Cayman Chemical
Cayman Chemical Company, headquartered in Ann Arbor, Michigan, was founded in 1980 by Kirk Maxey, M.D. The company's goal is to help make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative stress, endocrinology, and many more. Cayman Chemical specializes in assay kits for the detection of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.
More information at: www.caymanchem.com
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Torin 1
Item number: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Keywords: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Application: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
From 224.00€
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(±)19(20)-EpDPA
Item number: Cay10175-500
(±)-19(20)-EpDPA is an epoxide metabolite of docosahexaenoic acid (DHA, Cay-90310, Cay-17950). It is formed from DHA by various cytochrome P450 (CYP) isoforms. In vivo, (±)-19(20)-EpDPA (100 ng/animal, i.p.) suppresses hepatic crown-like structure (hCLS) formation and liver fibrosis in wild-type, but not...
| Keywords: | (±)19,20 EDP, (±)19,20-EpDPE, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA,... |
| Application: | CYP450 metabolism studies |
| MW: | 344.5 D |
From 70.00€
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12-oxo Phytodienoic Acid
Item number: Cay88520-1
12-oxo Phytodienoic acid (OPDA) is a biologically active, immediate precursor of 7-epi jasmonic acid. In addition to its link with jasmonic acid activity, OPDA appears to play an independent role in mediating resistance to pathogens and pests. As an endogenous signal transducer, OPDA has been shown to increase...
| Keywords: | 12-oxo PDA, OPDA, 4-oxo-5alpha-2Z-pentenyl)-2-cyclopentene-1alpha-octanoic acid |
| Application: | Bioactive lipid assays |
| CAS | 85551-10-6 |
| MW: | 292.4 D |
From 132.00€
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G-418 (sulfate)
Item number: Cay13200-5
G-418 is an aminoglycoside antibiotic. It is active against T. thermophila (IC50 = 10 µM). It inhibits the 80S ribosome and protein elongation during translation in a cell-free assay when used at a concentration of 2 nM. G-418 is used in molecular biology as a selective agent in cell lines or plasmids containing the...
| Keywords: | Geneticin,... |
| Application: | Antibiotic |
| CAS | 108321-42-2 |
| MW: | 692.7 D |
From 87.00€
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Leukotriene D4
Item number: Cay20310-25
Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Cay-20210) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by gamma-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal...
| Keywords: | LTD4, 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 73836-78-9 |
| MW: | 496.7 D |
From 239.00€
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Fingolimod (hydrochloride)
Item number: Cay10006292-50
Fingolimod is an immune modulator, a prodrug form of the sphingosine-1-phosphate (S1P) receptor agonist FTY720 phosphate (Cay-10008639), and a derivative of myriocin (Cay-63150). It selectively inhibits calcium-dependent cytosolic phospholipase A2 (cPLA2) over calcium-independent PLA2 (iPLA2) and secretory PLA2...
| Keywords: | FTY720, 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride |
| Application: | Immune Modulator |
| CAS | 162359-56-0 |
| MW: | 343.9 D |
From 116.00€
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Leukotriene C4
Item number: Cay20210-25
Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A)...
| Keywords: | LTC4, 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 72025-60-6 |
| MW: | 625.8 D |
From 239.00€
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Thromboxane B2-d4
Item number: Cay319030-25
Thromboxane B2-d4 (TXB2-d4) is intended for use as an internal standard for the quantification of TXB2 (Cay-19030) by GC- or LC-MS. TXB2 is a non-enzymatically derived, stable, inactive metabolite of TXA2, which is highly unstable. Serum levels of TXB2 positively correlate with platelet COX-1 activation. Urinary...
| Keywords: | TXB2-d4, 9alpha,11,15S-trihydroxy-thromba-5Z,13E-dien-1-oic-3,3,4,4-d4 acid |
| Application: | Standard |
| CAS | 1346112-79-5 |
| MW: | 374.5 D |
From 280.00€
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Protein Phosphatase 2A C subunit (human, recombinant,...
Item number: Cay10011237-10
Reversible protein phosphorylation is a fundamental regulatory mechanism in all aspects of biology. Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation and is also...
| Keywords: | RP-C, RP-C, PPP2CA, PP2A-alpha, PP2A-alpha, Replication protein C, Replication protein C, Serine/threonine-protein... |
| Application: | Enzyme activity |
| MW: | 38,6 kD |
440.00€
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Wortmannin
Item number: Cay10010591-1
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from...
| Keywords: | KY 12420,... |
| Application: | PI3K inhibitor |
| CAS | 19545-26-7 |
| MW: | 428.4 D |
From 74.00€
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2-deoxy-D-Glucose
Item number: Cay14325-1
2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis. It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate. 2-deoxy-D-glucose (16 mM) induces apoptosis in...
| Keywords: | Ba 2758, NSC 15193, 2-deoxy-D-arabino-hexose |
| Application: | Non-metabolizable glucose analog |
| CAS | 154-17-6 |
| MW: | 164.2 D |
From 82.00€
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5(S)-HETE-d8
Item number: Cay334230-25
5(S)-HETE-d8 is intended for use as an internal standard for the quantification of 5-HETE by GC- or LC-MS. (±)5-HETE is formed via non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 5(S)- and 5(R)-HETE are formed by lipoxygenase-mediated oxidation of arachidonic acid.Formal Name:...
| Keywords: | 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| Application: | Standard |
| CAS | 330796-62-8 |
| MW: | 328.5 D |
From 305.00€
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