Products from BPS Bioscience
Sun, sea, and science: BPS Bioscience from San Diego, California promotes new scientific discoveries that lead to therapies by creating innovative solutions for research. BPS is an expert in recombinant proteins and enzymes, cell lines, virus-based tools, as well as biochemical and cellular assay systems. The high-quality products and services from BPS enable researchers worldwide to advance biological discoveries in a variety of disciplines, including epigenetics, cell signaling, SARS-CoV-2, immunotherapy, CRISPR, and adoptive cell therapies.
More information at: www.bpsbioscience.com
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Chemi-Verse(TM) CDK2/CyclinA2 Kinase Assay Kit
Item number: BPS-82247
The Chemi-Verse(TM) CDK2/CyclinA2 Kinase Assay Kit is designed to measure CDK2 (cyclin dependent kinase 2)/CyclinA2 kinase activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant CDK2/CyclinA2...
| Keywords: | CDK2, CDKN2, p33 protein kinase, Cyclin-dependent kinase 2, Cell division protein kinase 2, |
| Application: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Species reactivity: | human |
842.00€
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Chemi-Verse(TM) CDK5/p35 Kinase Assay Kit
Item number: BPS-82249
The Chemi-Verse(TM) CDK5/p35 Kinase Assay Kit is designed to measure CDK5 (cyclin dependent kinase 5)/p35 kinase activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant CDK5/p35 complex,...
| Keywords: | EC=2.7.11.1, TPKII catalytic subunit, Cyclin-dependent kinase 5, Cell division protein kinase 5, Cyclin-dependent-like... |
| Application: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Species reactivity: | human |
842.00€
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Molecular Glue/PROTAC(R) Optimization Kit for RBM39-DCAF15
Item number: BPS-82251
The Molecular Glue/PROTAC(R) Optimization Kit for RBM39-DCAF15 Binding is designed for the testing and profiling of Molecular Glues (MG)/PROTACs targeting the RBM39 (RNA-binding protein 39) and DCAF15 (DDB1 and CUL4 associated factor 15) interaction. The Molecular Glue/PROTAC(R) Optimization Kit for RBM39-DCAF15...
| Keywords: | CAPERalpha, CAPER alpha, Splicing factor HCC1, RNA-binding protein 39, RNA-binding motif protein 39, Hepatocellular... |
| Application: | RBM39 targeting Molecular Glue/PROTAC identification/optimization, DCAF15 targeting molecule design |
| Species reactivity: | human |
4,961.00€
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Exatecan Mesylate
Item number: BPS-82255-1
Exatecan Mesylate is a structural analog of camptothecin with increased water solubility, and it shows anticancer activity.
| Application: | Camptothecine derivative, antineoplastic, topoisomerase I inhibitor, ADC payload |
| MW: | 531,6 D |
From 442.00€
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Human CD4 Lentivirus (Hygromycin)
Item number: BPS-78987
The Human CD4 Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain CD4 (NM_000616.5) driven by an EF1a promoter, and a hygromycin selection...
| Keywords: | CD4, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, |
| Application: | CD4-MHC class II interaction studies, cell pool/stable cell line generation, hygromycin selection |
| Species reactivity: | human |
1,555.00€
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Influenza A Virus HA TCR Lentivirus (Clone HA1.7)
Item number: BPS-78988-1
The Influenza A Virus HA TCR Lentivirus (Clone HA1.7) are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. These particles transduce cells with human TCR (T-cell receptor) clone HA1.7...
| Application: | Positive control, influenza res., cell pool/stable cell line generation following puromycin selection |
| Species reactivity: | Influenza A Virus |
From 1,643.00€
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Gambogic acid
Item number: BPS-82079-1
Gambogic acid is a natural product isolated from the resin of Garcinia hurburyi tree, Gambogic acid is a potent apoptosis inducer. It binds covalently to the regulatory subunit B (SPTSSB) of the serine palmitoyltransferase complex and inhibits de novo sphingolipid biosynthesis. Gambogic acid activates caspases in...
| Application: | Sphingolipid de novo biosynthesis inhibitor, potent apoptosis inducer |
| MW: | 628,8 D |
From 346.00€
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Hemiasterlin
Item number: BPS-82083-1
Hemiasterlin (SC209) is employed in crafting antibody-drug conjugates (ADCs) targeting EGFR, enabling the development of precision therapeutics tailored for improved efficacy against specific cancer types.
| Keywords: | SC209, |
| Application: | Antibody-drug conjugate (ADC) payload, cytotoxic |
| MW: | 488,7 D |
From 1,739.00€
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Tucatinib
Item number: BPS-82084-1
Tucatinib acts as an HER2 inhibitor, and in BT474 breast carcinoma cells, it effectively suppresses HER2 phosphorylation. Tucatinib inhibits AKT phosphorylation and induces apoptosis in BT474 cells, rendering it a viable cytotoxic agent for formulating antibody-drug conjugates (ADCs).
| Application: | HER2 inhibitor, ADC payload |
| MW: | 480,5 D |
From 869.00€
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SN-38
Item number: BPS-82257-1
SN-38 is an anti-tumor drug that is often linked to ADCs to be directly delivered to cells. It is also the active metabolite of the drug, irinotecan. Its mechanism of action is inhibition of DNA topoisomerase I, halting DNA synthesis and causing single-strand breaks in DNA.
| Keywords: | 7-Ethyl-10-hydroxycamptothecin, |
| Application: | Anti-tumor drug , active irinotecan metabolite, ADC payload |
| MW: | 392,4 D |
From 731.00€
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Doxorubicin HCl
Item number: BPS-82260-1
Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin.
| Keywords: | Doxorubicin HCl salt, |
| Application: | Anthracycline antibiotic, antineoplastic, topoisomerase II inhibitor, ADC payload |
| MW: | 543,5 D |
From 496.00€
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N-(Iodoacetamido)-Doxorubicin
Item number: BPS-82261-1
N-(Iodoacetamido)-Doxorubicin is an iodine attached Doxorubicin. It can conjugate with molecules containing thiol, amine functional groups. Doxorubicin is an anthracycline antibiotic with antineoplastic activity.
| Application: | Topoisomerase II inhibitor derivate, ADC payload (thiol/amine functional groups) |
| MW: | 711,5 D |
From 1,739.00€
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